Pirfenidone Pirespa PFD Powder Esbriet For Idiopathic Pulmonary Fibrosis Treatment

Pirfenidone Pirespa PFD Powder Esbriet For Idiopathic Pulmonary Fibrosis Treatment

Esbriet, also known by the generic name of pirfenidone, is an antifibrotic agent commonly prescribed as a treatment for mild to moderate cases of idiopathic pulmonary fibrosis (IPF). The drug has both an anti-inflammatory and anti-fibrotic action, key signaling pathways in IPF. Specifically, by reducing secretion and inhibition of TGF-β, and inflammatory mediators like TNF-α and IL-1β.

What is Pirfenidone?

Pirfenidone is a prescription medicine used to treat people with a lung disease called idiopathic pulmonary fibrosis (IPF).

FDA approval of two new drugs for idiopathic pulmonary fibrosis (Pirfenidone and Ofev) offers new hope for patients who live with this deadly, incurable disease.

The U.S. Food and Drug Administration has approved pirfenidone, a TGF-beta synthesis inhibitor for the treatment of patients with idiopathic pulmonary fibrosis (IPF).

Before taking Pirfenidone:
Before you start treatment, tell your doctor if you:

• have liver problems
• have kidney problems
• are a smoker
• have any other medical conditions
• are pregnant or plan to become pregnant. It is not known if the drug will harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if the drug passes into your breast milk. You and your doctor should decide if you will take Pirfenidone or breastfeed.

Tell your doctor about all the medicines you take, including prescription and over-the­counter medicines, vitamins, and herbal supplements.

How should I take Pirfenidone?

• Take this medicine exactly as your doctor tells you to take it.
• Your doctor may change your dosage as needed.
• Take the medication with food. This may help to decrease nausea and dizziness.
• If you miss a dose, take your next dose as soon as you remember.
• Do not take two doses at the same time to make up for your missed dose.
• Do not take more than three doses each day.
• If you overdose, call your doctor or go to the nearest hospital emergency room right away.
• Your doctor should do certain blood tests before you start treatment.

What should I avoid while taking Pirfenidone?

• Avoid sunlight. Pirfenidone can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get a severe sunburn. Use sunscreen (SPF50) and wear a hat and clothes that cover your skin if you have to be in sunlight. Talk to your doctor if you get sunburn.
• Avoid smoking. Smoking may affect how well the medicine works.

Pirfenidone side effects

Pirfenidone may cause serious side effects, including:

• liver problems.Call your doctor right away if you have unexplained symptoms such as yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea colored) urine, pain on the upper right side of your stomach area (abdomen), bleeding or bruising more easily than normal, feeling tired. Your doctor will do blood tests to check how your liver is working during your treatment.
• sensitivity to sunlight (photosensitivity) and rash.
• stomach problems such as nausea, vomiting, diarrhea, indigestion, heartburn, and stomach pain may occur. Tell your doctor right away if your stomach problems get worse or do not go away. Your doctor may need to change your dose.

The most common side effects include feeling tired, headache, dizziness and decreased or loss of appetite.
These are not all the possible side effects. For more information, ask your doctor or pharmacist.

How should I store Pirfenidone?

• Store the tablets at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep in a tightly closed container.
• Safely throw away any Pirfenidone that is out of date or no longer needed.
• Keep all medicines out of reach of children.

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