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| Name: | Tacrolimus | CAS: | 109581-93-3 |
|---|---|---|---|
| Appearance: | White Powder Tacrolimus | MOQ: | 100 G Tacrolimus |
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| High Light: | Natural Plant Extract,Raw Hormone Powders |
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Pharmaceutical Raw Materials Tacrolimus CAS 109581-93-3 Immune Suppressant
Tacrolimus Basic Info
Name: Tacrolimus
CAS No.: 104987-11-3
Purity: 99.5%
MF: C44H69NO12
MW: 804.02
Density: 1.19 g/cm3
Melting Point: 113-115° C
Boiling Point: 871.7 ° C at 760 mmHg
Vapour: 1.73E-35mmHg at 25° C
Refractive Index: 1.549
Flash Point: 481 ° C
Usage: An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Tacrolimus Description:
heart liver kidney and bone marrow transplant patients preferred immune-suppressing drugs after the transplant rejection resistant to conventional immunosuppressive regimen, is also the choice of the drug... Adverse reactions similar to cyclosporine. autoimmune eye disease and other autoimmune diseases also play an active role.
Tacrolimus Applications:
It has similar immunosuppressive properties to ciclosporin, but is much more potent. Immunosuppression with tacrolimus was associated with a significantly lower rate of acute rejection compared with ciclosporin-based immunosuppression (30.7% vs 46.4%) in one study. Clinical outcome is better with tacrolimus than with ciclosporin during the first year of liver transplantation. Long term outcome has not been improved to the same extent. Tacrolimus is normally prescribed as part of a post-transplant cocktail including steroids, mycophenolate and IL-2 receptor inhibitors. Dosages are titrated to target blood levels. Typical starting doses for once daily tacrolimus are 0.15-0.20 mg/kg body weight.
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Tacrolimus COA
| Tests | Specifications | Results |
| Description | A white or off-white crystalline powder | Conform |
| Identification | 1. IR (USP <197K>) | Conform |
| 2. HPLC retention times | Conform | |
| Water (USP <921> Method I) |
1.6 ~ 3.0% | 2.1% |
| Residue on ignition (USP <281>) |
£ 0.2% | 0.08% |
| Heavy metals (USP <231> II) |
£ 20 ppm | < 20 ppm |
| Related substances (In-house HPLC method) | Ascomycin £ 0.8% | 0.064% |
| Residual solvents (In-house method) |
Acetone £ 2000 ppm | Not detected |
| Assay (on anhydrous basis) | 98.0% ~ 102.0% | 100.0% |
| Conclusion: Complied with Enterprise standard | ||
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