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|Appearance:||White Powder Aicar||MOQ:||10 G Aicar|
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AICAR, also known as acadesine, is a synthetic adenosine monophosphate (AMP) analog that activates activated protein kinase (AMPK), which plays a role in cellular energy homeostasis; ATP (adenosine triphosphate) is produced by mitochondria as a readily available energy source for chemical processes in the cell. When cells become energy deprived, AMP accumulates. When the cell detects any low energy state from the concentration of AMP present, AMPK is activated.
The activation of AMPK increases the conversion of fuel sources, such as fatty acids, into ATP. Activating AMPK causes the same processes to occur that take place when the cell is energy deprived from exercise or low calorie intake. AIRCAR has been shown to be effective at activating AMPK as if exercise was performed, or energy stores were low and fat needed to be burned as fuel.
AICAR Quick Detail
Appearance: White powder
Usage: Glucose uptake stimulant; AMPK activator; Usage AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
AICAR’s principal mechanism of action is activation of AMPK (AMP-activated protein kinase.) As is well known, ATP (adenosine triphosphate) is produced by mitochondria as a ready-to-use energy source for biochemical processes in the cell. These processes do not use glucose, fats, or fatty acids directly as energy sources: these must first be metabolized in the mitochondria to yield ATP. When ATP is used for energy, its first product is ADP (adenosine di-phosphate), and then – if the cell is really deprived of immediate sources of energy – finally to AMP (adenosine monophosphate.)
AMP only accumulates as a cell becomes energy-deprived. Accordingly, there’s a system where the cell detects any low energy state from the concentration of AMP that’s present, and activates AMPK in response.
AMPK in turn ramps up conversion of fuel sources, including fatty acids, into ATP, as well as stimulating quite a number of other systems in the cell.
Activating AMPK, therefore, causes the same cellular machinery (so to speak) to be turned on as if the cell were energy deprived, for example from intensive exercise, or from low caloric intake.
AICAR, at sufficient and quite substantial concentration, is effective at activating AMPK and inducing a cellular state as if exercise had been performed, or energy stores were low and fat therefore needed to be burned.
|Related substance (HPLC)||Total impurity ≤0.5%
Max single impurity ≤0.1%
|Sieve analysis||100% pass 80 mesh||Complies|
|Loss on Drying
Residue on Ignition
|Total Plate Count||<1000cfu/g||Complies|
|Yeast & Mold||<100cfu/g||Complies|
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