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Powerful Male Sex Improvement Sildenafil Citrate Male Sex Hormones CAS 171599-83-0
Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension (PAH). It was originally discovered by Pfizer scientists Andrew Bell, David Brown, and Nicholas Terrett.
The primary indication of sildenafil is treatment of erectile dysfunction (inability to sustain a satisfactory erection to complete intercourse). Its use is now standard treatment for erectile dysfunction in all settings, including diabetes.It acts by inhibiting cGMP-specific phosphodiesterase type 5 (PDE5), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.
As well as erectile dysfunction, sildenafil citrate is also effective in the rare disease pulmonary arterial hypertension. It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This, in turn, reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure. Because PDE5 is primarily distributed within the arterial wall smooth muscle of the lungs and penis, sildenafil acts selectively in both these areas without inducing vasodilation in other areas of the body. Pfizer submitted an additional registration for sildenafil to the United States Food and Drug Administration (FDA), and sildenafil was approved for this indication in June 2005. The preparation is named Revatio, to avoid confusion with Viagra, and the 20-mg tablets are white and round. Sildenafil joins bosentan and prostacyclin-based therapies for this condition.
|Product Name||Sildenafil Citrate|
|Packing||1kg net/foil bag, 5kg/drum.|
|Appearance||White Solid. mp 187-189¡ãC|
|Storage||Shading , Confined Preservation|
|Usage||An orally active selective type 5 cGMP phosphodiesterase inhibitor. pharmaceutical material|
|Biological Activity||Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro .|
Sildenafil Citrate treats erectile dys function and works by relaxing muscles and increases blood flow to particular areas of the body (in this case, the penis, specifically). Its effects last up to four hours.
As well as treating impotence, Sildenafil Citrate can also be effective in treating Pulmonary Arterial Hypertension (PAH). Similarly to how it acts to relax muscles of the penis, it relaxes arterial walls; therefore, reducing resistance and pressure in the arteries.
Sildenafil Citrate is solely active in relaxing muscles and increasing blood flow to the heart, lungs and penis due to PDE-5, yet vasodilation is not increased in other parts of the body.
Common side effects include headaches and heart burn, as well as flushed skin. Caution is advised in those who have cardiovascular disease. Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss. Sildenafil should not be taken by people who take nitrates such as nitroglycerin, as this may result in a severe and potentially fatal drop in blood pressure.
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|Product name||Sildenafil Citrate|
|Production date||Sep.2016||Shelf life||Aug.2021|
|Items of analysis||Specification||Results|
|Description||white or almost white,slightly hygroscopic crystalline powder.||almost white,slightly hygroscopic crystalline powder.|
|solubility||slightly soluble in water and in methanol,practically insoluble in hexane.||slightly soluble in water and in methanol,practically insoluble in hexane.|
|identification by IR||The infrared absorption spectrum of the potassium bromide dispersion of the sample preparation should be exhibit max.only at the same wave numbers as that of a similar preparation of sildenafil citrate working standara/Reference standards.||the infrared absorption spectrum of the potassium bromide dispersion of the sample preparation is exhibit ma.only at the same wave numbers as that of a similar preparation of sildenafil citrate working standard.|
|limit of imidazole by TLC(%)||Not more than 0.1||less than 0.1|
|organic impurities by HPLC(%,w/w)|
|related compound-A||not more than 0.3%||0.02%|
|Any other unspecified individual impurity||not more than 0.10%||0.04%|
|Total unspecified impurities||not more than 0.3%||0.06%|
|Total impurities||not more than 0.5||0.08|
|water conten by KF(%,w/w)||not more than 2.50% w/w||0.82% w/w|
|residue on ignition(%,w/w)||not more than 0.1||0.06|
|heavy metals(ppm)||not more than 20||less than 20|
|assay by HPLC(anhydrous and solvent free basis(%,w/w)||98-102||99.46|
|residual solvents by GC(ppm)|
|acetone||not more than 5000ppm||ND|
|methylene chloride||not more than 600ppm||ND|
|ethyl acetate||not more than 5000ppm||ND|
|Toluene||not more than 890ppm||ND|
|Methanol||not more than 3000ppm||29ppm|
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