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|Appearance:||White Powder Ethisterone||MOQ:||100 G Ethisterone|
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Steroid Powder Ethisterone Progestogen Hormone CAS 434-03-7 For Bodybuilding
Ethisterone Basic Info
Synonyms: 17a-Ethynyl testosterone; Anhydrohydroxyprogesterone
Molecular Formula: C21H28O2
Molecular Weight: 312.45
Melting point: 266-273 ºC
Usage: Ethisterone use to be Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone.
Ethisterone also known as 17α-ethinyltestosterone, pregneninolone, or anhydrohydroxyprogesterone, is a steroidal progestin with androgenic activity which is derived from testosterone and was introduced for medical use in 1939 and was both the first orally active progestogen and the first progestin (or synthetic progestogen) to be introduced.Although ethisterone has largely been superseded by newer drugs and is now little used, it continues to be available in some countries.the 19-nortestosterone progestins, such as norethisterone, are derived from ethisterone and are widely used as hormonal contraceptives and for other indications.
Based on in vitro research, ethisterone and norethisterone are about equipotent in their EC50 values for the androgen receptor (AR), whereas, conversely, norethisterone shows markedly increased potency relative to ethisterone in terms of its EC50 for the progesterone receptor (PR). As such, there is a considerable separation in the ratios of androgenic and progestogenic activity for ethisterone and norethisterone.
Due to its androgenic activity, ethisterone has been associated with the masculinization of female fetuses in women who have taken it during pregnancy.
High dosages of norethisterone and noretynodrel, which are 19-nortestosterone derivatives of ethisterone, were found to be associated with high rates of estrogenic side effects such as breast enlargement in women and gynecomastia in men, as well as with improvement of menopausal symptoms in postmenopausal women.that they are either not estrogenic or are only weak so. As such, ethisterone does not appear to share the estrogenic activity of norethisterone and noretynodrel.
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