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Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer

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Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer

Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer
Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer

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Product Details:
Place of Origin: China
Brand Name: HEPIUS
Certification: SGS
Model Number: cas 521-18-6
Payment & Shipping Terms:
Minimum Order Quantity: 1bottle, 10ml per bottle
Price: Negotiated
Packaging Details: plastic bottle
Delivery Time: within 24 hours after the payment
Payment Terms: Bank Transfer, T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 300bottles/month
Detailed Product Description
Name: Stanolone Specification: 50mg/ml 10ml Per Bottle
Shipping Method: Fedex, DHL, UPS, USPS, EMS, ETK... Apperance: Injection Oil
Usage: Medicine, Breast Cancer Whatsapp: +8613119583676
Payment: Money Gram, Western Union, Bank Transfer, Bitcoin Policy: Reshipping Policy

Injectable Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer

 

What is Stanolone?

 

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT) is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor with 2-3-fold greater androgen receptor affinity than testosterone and 10-fold higher potency of inducing androgen receptor signaling.

 

In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increased the expression of EGFR and ERBB2 both in mRNA and in protein levels. DHT additionally upregulated the levels of phosphorylation of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment, in AR-positive cells.

 

Bladder cancer cells at a density of 50-60% confluence in 24-well plates are co-transfected with 250 ng of MMTV-luc reporter plasmid DNA and 2.5 ng of PRL-TK-luc plasmid DNA. After 6 h of transfection, the medium is replaced with another medium supplemented with charcoal-stripped FBS in the presence or absence of ligands (DHT, HF, or both) for 24 h. Cells were harvested, lysed, and assayed for luciferase activity.

 

Description

 

Stanolone is well known as dihydrotestosterone (DHT), which is an endogenous androgen sex steroid and hormone. It is an agonist of the androgen receptor (AR). It plays important physiological role in sexual differentiation, maturation of the penis and scrotum, hair, sebum production and development and maintenance of the prostate gland and seminal vesicles. It is mainly used for the treatment of male hypogonadism, androgen deficiency of severe illness, androgen deficiency of ageing and microphallus in infancy.

 

Chemical Properties

 

White Crystalline Solid

 

Originator

 

Neodrol,Pfizer,US,1953

 

Uses

 

Anabolic steroid. Controlled substance

 

Definition

 

ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with alpha- configuration at position 5.

 

Manufacturing Process

 

A solution of 1.0 g of 3,17-androstandione in 50 ml of methanol and containing 1 g of selenium dioxide, was allowed to remain in an ice-chest overnight. The formed 3,3-dimethoxyandrostan-17-one was not separated. 1 g of solid potassium hydroxide and 2.5 g of sodium borohydride in 2.5 ml of water were added and the mixture allowed to react at room temperature for 24 hours. The solution was then poured into a large excess of water, extracted with methylene chloride, the organic layer dried and evaporated to a residue. The residue was dissolved in ether, and a small amount of selenium removed by filtration. The ether was boiled off and the organic material dissolved in 100 ml of boiling acetone. 25 ml of diluted hydrochloric acid were added, the solution boiled for 5 minutes and then allowed to cool. Upon crystallization, 0.85 g of androstan-17β-ol-3-one was obtained, melting point 175°C to 178°C.

 

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Injectable 50mg Stanolone DHT CAS 521-18-6 Anabolic Steriods for Breast Cancer 0

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